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Example Questions
Example Question #1 : Central Dogma Of Biology
Which of the following best illustrates the central dogma of biology in terms of how a cell makes proteins?
DNA from the chromosomes first undergoes transcription to generate RNA. This RNA then undergoes translation, which is the process by which the genetic code is used to make necessary proteins.
Example Question #1 : Central Dogma Of Biology
In the central dogma of biology, what is the name of the process that lies between RNA and protein? I.e., what process does the cell use to make protein from RNA?
Expression
Transcription
Replication
Translation
Suppression
Translation
Translation is the process in which RNAs are "read" by ribosomes, and the appropriate protein is made.
Example Question #2 : Central Dogma Of Biology
If a DNA strand has the following sequence, choose the answer that has the correct mRNA sequence.
3' ATTAGCAC 5'
TAATCGTG
ATTAGCAC
CACGATTA
GCCACTTA
UAAUCGUG
UAAUCGUG
The mRNA will be complementary to the DNA sequence, but remember that mRNA has a uracil (U) base instead of thymine (T). If the base on the left is the DNA, the corresponding mRNA code is:
UAAUCGUG
Example Question #3 : Central Dogma Of Biology
If a DNA coding strand has the following sequence, which of the following is the sequence of the DNA template strand?
3' ACTGTTAC 5'
ACTGTTAC
TGACAATG
ACUGUUAC
TGUCUUTG
GCCGTTAC
TGACAATG
The DNA template strand will be complementary to the DNA coding strand sequence. If the base on the left is the coding DNA, the corresponding template DNA strand code is:
TGACAATG
Example Question #1 : Central Dogma Of Biology
Which of the following best describes the role of the enzyme helicase?
Unzip DNA strands by breaking the bonds between the two strands.
Ligating broken strands back together
Separating double-stranded RNA by breaking bonds
Repairing damaged DNA
Copying the DNA for replication
Unzip DNA strands by breaking the bonds between the two strands.
Helicase is the enzyme that breaks the bonds between the coding and template strands of DNA so that the other DNA replication machinery can access the codes. The other functions listed are important roles, but can be attributed to other enzymes.
Example Question #2 : Central Dogma Of Biology
What is the central dogma of biology?
DNA to RNA to protein
DNA to mRNA to protein to tRNA
Protein to RNA to DNA
Protein to DNA to RNA
DNA to protein to RNA
DNA to RNA to protein
The central dogma of biology is best described by DNA is transcribed to RNA, which is translated to protein. The genetic material (DNA) is transcribed into mRNA (RNA) which is than translated into proteins. The central dogma is an important principle in molecular biology, and it helps explain why DNA plays such an important role in genetic expression.
Example Question #11 : Central Dogma Of Biology
All of the following organisms follow the central dogma except __________.
Algae
Deathcap
HIV
Botulism
HIV
The central dogma of biology reads that DNA goes to RNA which goes to protein. All of the following do that except for HIV, which uses reverse transcriptase in order to convert RNA to DNA which is going in reverse of the central dogma.
Example Question #11 : Central Dogma Of Biology
A gene is the DNA segment necessary to create a protein.
What sections of the DNA are included in a gene?
Length of DNA from a single chromosome
Poly-A tail and 5' cap
Promoter region of DNA
DNA encoding mRNA and promoter region of DNA
DNA encoding mRNA
DNA encoding mRNA and promoter region of DNA
Given the definition that a gene is the segment of DNA necessary to create a protein, we can immediately eliminate the choices of "Poly-A tail and 5' cap" and "Length of DNA from a single chromosome." Neither of these choices correspond to a segment of DNA: the first corresponds to segments of processed mRNA, and the second to the entire length of the DNA unsegmented. Neither "DNA encoding mRNA" or "Promoter region of DNA" can be correct, as they cannot function without the other, with the promoter region allowing proteins to prepare for transcription of the DNA-encoding mRNA to be produced.
Example Question #12 : Central Dogma Of Biology
What is the role of the promoter region of DNA in transcription?
To be a template for the mRNA strand to be transcribed.
To open DNA upstream of the promoter region
To initiate transcription of a particular gene
To open DNA downstream of the promoter region
To change the conformation of the DNA (i.e. double helix to parallel)
To initiate transcription of a particular gene
The promoter region of DNA does not interact with the shape of the DNA around it, eliminating all choices where change in DNA shape occurs. This leaves the answer choices of "To be a template for the mRNA strand," and "To initiate transcription of a particular gene." The promoter region is not transcribed to the mRNA that it initiates, leaving the correct answer, "To initiate transcription of a particular gene." The promoter region does this by attracting transcription factors necessary for recruitment of RNA polymerase.
Example Question #13 : Central Dogma Of Biology
Where does transcription take place?
On ribosomes
Inside of the nucleus
Inside of the mitochondria
On the outer cell membrane of the nuclear envelope
Inside of the rough endoplasmic reticulum
Inside of the nucleus
The central dogma of biology occurs inside of the nucleus from DNA to modified mRNA transcripts prepared to be exported to the cytoplasm. Since the nucleus is an organelle separated from the endoplasmic reticulum and the mitochondria, those answers can be eliminated. Translation occurs on ribosomes, not transcription. It is an important distinction that transcription occurs entirely within the membranes of the nucleus, and would not be found on the outer membrane of the nuclear envelope.