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Genetics Question of the Day

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Monday, September 21, 2026

The template strand of a bacterial gene contains the sequence 3'-...GCA GGT ACT...-5' corresponding to the 5th, 6th, and 7th codons. What is the sequence of the anticodon, written 5' to 3', on the tRNA that recognizes the 6th codon?

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The template strand of a bacterial gene contains the sequence 3'-...GCA GGT ACT...-5' corresponding to the 5th, 6th, and 7th codons. What is the sequence of the anticodon, written 5' to 3', on the tRNA that recognizes the 6th codon?

  1. 5'-CCA-3'
  2. 5'-UGG-3' (correct answer)
  3. 5'-GGU-3'
  4. 3'-CCA-5'

Explanation: The process involves several steps: 1) The DNA template triplet is 3'-GGT-5'. 2) The mRNA codon is transcribed complementary and antiparallel to the template, resulting in 5'-CCA-3'. 3) The tRNA anticodon must be complementary and antiparallel to the mRNA codon. Thus, it is 3'-GGU-5'. 4) By convention, nucleic acid sequences are written 5' to 3'. Therefore, the anticodon is 5'-UGG-3'.