Help with Stomach Physiology - Anatomy

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Question

Which stomach cell is responsible for the activation of pepsinogen?

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Answer

Pepsinogen is an inactive enzyme that is released into the stomach lumen by chief cells. Parietal cells are responsible for secreting hydrochloric acid. This acid will cleave the pepsinogen and make it an active enzyme, pepsin, which can then cleave peptide bonds and begin protein digestion.

Goblet cells secrete mucus to protect the epithelium of the stomach from the acid in the lumen. G cells secrete gastrin, which promotes the secretion of hydrochloric acid and pepsinogen.

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