Systems Physiology - AP Biology

Major histocompatibility complex (MHC) class I molecules are found on virtually all cells in the body. They function in routine immune monitoring through presentation of short peptide fragments derived from degradation of intracellular proteins contained within the cell. The T-cell receptor on cytotoxic T-cells interacts with MHC class I, and if a foreign pathogen or peptide is presented, the cytotoxic T-cell becomes activated to kill infected cells. The same system also functions for detection of potential cancer cells.

The immune system is very adaptive. The body has many antibodies that will each recognize different antigens. If an antibody binds to an antigen, the antibody will be copied so that the body can quickly recognize the threat if it is exposed to the antigen a second time. This process is known as the adaptive immune response.

When an antigen is presented for a second time, antibodies to the antigen are released. These antibodies bind to the antigen, labelling it for attack by immune cells and preventing it from interacting the membrane proteins on the host cells.

Antibodies are proteins created by the immune system in order to neutralize foreign objects. An antibody would not be classified as an enzyme because it does not catalyze chemical reactions. When a foreign pathogen enters the body, it will have foreign receptors on its surface. These foreign receptors are known as antigens. When a pathogen is destroyed, immune cells can carry a sample of the antigen to the T-cells for identification. The T-cells help activate B-cells that will synthesize an antibody against the particular antigen. The selected B-cells differentiate into plasma cells and secrete antibody proteins into the blood, which bind the antigens and label the pathogen as foreign. This label attracts other immune cells to attack and destroy the pathogen.

Antibodies are continuously made in the body in different shapes and forms. They are then sent into the blood stream to test for the presence of compatible antigens. Each antibody can only bind to one antigen, and each antigen can only bind to one antibody. Think of them like a codon-anticodon pair; there is only one possibility for them to form a perfectly complementary pair. Once the correct antibody binds to an antigen, they are tagged and used to stimulate production of more antibodies. The antibodies are only capable of binding and tagging the antigens. Cytotoxic T-cells are then able to recognize antibody binding patterns and actually destroy the infected cell.

From the passage, the MHC I molecule's blueprint is on chromosome 6. Therefore, the DNA must have been transcribed in the nucleus then translated in the ribosome. These ribosomes are on the endoplasmic reticulum. While in the endoplasmic reticulum, some of these proteins are degraded and react with a particular MHC I molecule.

According to the passage, after the MHC II molecules are fully synthesized in the endoplasmic reticulum, they are transported to the endosome. Foreign molecules are transported into the cell where they are degraded in the endosome as well. From there, the degraded pathogen interact with the MHC II molecule.

According to the passage, MHC I and cytotoxic t-cells are responsible for identifying the body's own protein. During organ transplant, foreign MHC I molecules are presented into the body. The host's cytotoxic T-cells will recognize these as foreign and will attack.

White blood cells is the correct answer here. After pathogen has entered the body, the antibodies to combat it are created by B cells that are a part of the white blood cells in the human body.

The ability to form any of the three germ layers is known as pluripotency. Totipotent cells, such as the zygote, are able to form an entire organism, multipotent cells are able to form any cell within the same germ layer lineage, and progenitor cells are cells closer to differentiation, often found in adult organisms.

Humoral, or B-cell, immunity is associated with the formation of antibodies. Plasma cells are B-lymphocytes that have been differentiated with the help of a helper T-cell. They release antibodies, which are created to respond to a specific pathogen in the body.

Cytotoxic T-cells are also activates by help T-cells, but are involved in cell-mediated immunity rather than humoral immunity. They target infected cells based on antibody tagging. Monocytes are a part of the innate immune response and are not involved in antibody interactions. They primarily differentiate into macrophages, which engage in phagocytosis of pathogens.

Basophils are the least common leukocyte found in the body, but play a key role in the inflammatory response. They contain histamine, which is a potent vasodilator. Upon release, histamine will increase blood flow to infected areas. Mast cells are another immune cell that is involved in histamine release, but are generally localized to various regions of the body rather than found in circulation.

Basophils, mast cells, eosinophils, and neutrophils are all considered granulocytes and are essential cells in the innate immune response. Plasma cells are differentiated B-lymphocytes that are responsible for mass-producing antibodies to a specific antigen.

The granulocytes are responsible for numerous functions of innate immunity, from secreting histamine, to phagocytosis, to anti-inflammatory processes. These cells are the basophils, neutrophils, eosinophils, macrophages (monocytes), and mast cells.

Eosinophils have a more limited role in innate defense than the other granulocytes. They possess only low phagocytic activity, however, they are more specialized to respond to multi-cellular pathogens, such as parasitic worms. Rather than phagocytosing an invading organism, eosinophils function by releasing an arsenal of destructive enzymes and free radicals to ward off the organism. The other granulocytes are specialized for phagocytosis of bacteria, viruses, and cellular debris.

Each B-cell receptor is a Y-shape molecule that, upon maturation, can become a secretory form (an antibody). Each receptor is comprised of four polypeptide chains: two identical heavy chains and two identical light chains. The four chains are linked together by disulfide bridges. Both heavy and light chains consist of constant regions, as well as variable regions. The variable regions of each chain provide the specificity for antigen binding, which generates a signaling cascade within the B-cell.

The adaptive immune system primarily relies on the function of B-cells and T-cells. T-cells help recognize antigens to which the body has been previously exposed and stimulate B-cell to release antibodies to combat that specific antigen.

Upon initial antigen exposure, all other cell types listed (which help comprise the innate immune system) kick in.

Mast cells contains secretory granules, rich in histamine and other hormonal mediators, that promote inflammation and other allergy symptoms in response to antigen exposure.

The humoral response refers to the antiquated term "humors", meaning body fluids, as used in ancient and medieval medicine. In response to antigen exposure, B-cells release antibodies into the extracellular fluid and throughout the body, thus eliciting a "humoral response."

Although helper T-cells are responsible for activating B-cells, the humoral response is limited to B-cells because they are the ones releasing products into the body fluids.

Metastasis is the proliferation of cancer cells into new tissues. Cancer usually metastasizes through the circulatory or lymphatic systems, and the cancerous cells take residence in other, seemingly unrelated parts of the body.

Memory B cells circulate the body and are ready to respond to subsequent infections while plasma cells generate many antibodies to a current infect. "Immunoglobulins" refers to both the B cell receptor and to the excreted form of these proteins (known as antibodies). IgG is a class of immunoglobulins (along with IgA, IgE, IgD, and IgM). Finally, macrophages are cells that engulf non-self (and often antibody-bound) cells and communicate with T cells to promote B cell proliferation.

Red blood cells are made in the bone marrow, and live for about 3-4 months. They are enucleated (lacking a nucleus), which makes more space available for hemoglobin molecules, which function to carry oxygen to the tissues. HIV infects T-helper cells, which are white blood cells, not red blood cells. Thus, the name makes sense since the virus infects cells of the immune system (white blood cells) and causes immunodeficiency. The liver and spleen play roles in recycling the red blood cells once they have carried out their function for about 120 days.

Keratinocytes are not immune cells. Rather, they secrete a protein called keratin which is a large proportion of the extracellular matrix and makes up hair, nails, skin, and other parts of the body. All other cells are immune cells.