Lipid Synthesis Enzymes - Biochemistry
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In mammals, the enzyme used to synthesize fatty acids is called mammalian fatty acid synthase. It has 7 components that all work together to synthesize a fatty acid chain.
If the DH subunit of the enzyme is mutated and cannot catalyze its proper reaction, which functional group would you expect to see on the resulting carbon chain?
In mammals, the enzyme used to synthesize fatty acids is called mammalian fatty acid synthase. It has 7 components that all work together to synthesize a fatty acid chain.
If the DH subunit of the enzyme is mutated and cannot catalyze its proper reaction, which functional group would you expect to see on the resulting carbon chain?
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The DH subunit is a dehydratase, meaning it removes alcohol groups from carbon chains. If this subunit is mutated, the alcohol cannot be removed.
The DH subunit is a dehydratase, meaning it removes alcohol groups from carbon chains. If this subunit is mutated, the alcohol cannot be removed.
Malonyl-CoA is a potent inhibitor of carnitine palmitoyl transferase, which facilitates the movement of long-chain fatty acids into the mitochondria for beta-oxidation. This leads to decreased utilization of fatty acids for fuel.
If we wanted to eliminate this effect in a targeted manner, which enzyme would we seek to inhibit?
Malonyl-CoA is a potent inhibitor of carnitine palmitoyl transferase, which facilitates the movement of long-chain fatty acids into the mitochondria for beta-oxidation. This leads to decreased utilization of fatty acids for fuel.
If we wanted to eliminate this effect in a targeted manner, which enzyme would we seek to inhibit?
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Because acetyl-CoA Carboxylase (ACC) is directly responsible for synthesis of malonyl-CoA, inhibiting it would be the most targeted approach. Inhibiting acyl-CoA dehydrogenase or pyruvate dehydrogenase would decrease available acetyl-CoA to ACC by inhibiting beta-oxidation and conversion of pyruvate to acetyl-CoA, but this would have a large impact on other biosynthetic pathways as well, due to the ubiquity of acetyl-CoA.
Because acetyl-CoA Carboxylase (ACC) is directly responsible for synthesis of malonyl-CoA, inhibiting it would be the most targeted approach. Inhibiting acyl-CoA dehydrogenase or pyruvate dehydrogenase would decrease available acetyl-CoA to ACC by inhibiting beta-oxidation and conversion of pyruvate to acetyl-CoA, but this would have a large impact on other biosynthetic pathways as well, due to the ubiquity of acetyl-CoA.
Which coenzyme is common to reactions catalyzed by pyruvate dehydrogenase and β-hydroxybutyrate dehydrogenase?
Which coenzyme is common to reactions catalyzed by pyruvate dehydrogenase and β-hydroxybutyrate dehydrogenase?
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-hydroxybutyrate dehydrogenase catalyzes the interconversion of the ketone bodies acetoacetate and 
-hydroxybutyrate, which are transported out of liver cells into the blood to be used as fuel by the rest of the body, particularly during times of starvation. 
-hydroxybutyrate dehydrogenase’s only coenzyme is 
. As for the other answers: the pyruvate dehydrogenase complex converts pyruvate into acetyl-CoA, the key connection between glycolysis and the citric acid cycle, and this process uses a number of co-factors, including 
, thiamine pyrophosphate, lipoamide (the protein-bound form of lipoic acid), and, of course, coenzyme A (to make acetyl-CoA). Pyruvate dehydrogenase uses 
and 
depending on the cell type.
Which of the following is true about major lipoprotein metabolism pathways?
Which of the following is true about major lipoprotein metabolism pathways?
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The endogenous, not the exogenous, pathway, involves the transformation of VDLDs into LDLs. Meanwhile, the exogenous, not the endogenous, pathway, involves transforming chylomicrons into remnants. The apolipoprotein in plasma (transporting cholesterol to the liver) which is the major component of HDL is A1, not B100. Macrophages do indeed oxidize LDLs and transform themselves into the foam cells which indicate atherosclerosis. This is one of the reasons that LDL cholesterol levels can indicate atherosclerosis (which is associated with increased risk of heart attack or stroke).
The endogenous, not the exogenous, pathway, involves the transformation of VDLDs into LDLs. Meanwhile, the exogenous, not the endogenous, pathway, involves transforming chylomicrons into remnants. The apolipoprotein in plasma (transporting cholesterol to the liver) which is the major component of HDL is A1, not B100. Macrophages do indeed oxidize LDLs and transform themselves into the foam cells which indicate atherosclerosis. This is one of the reasons that LDL cholesterol levels can indicate atherosclerosis (which is associated with increased risk of heart attack or stroke).
The enzyme Acyl-Carrier Protein (ACP) plays an important role in the biosynthesis of which of the following?
The enzyme Acyl-Carrier Protein (ACP) plays an important role in the biosynthesis of which of the following?
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Acyl-Carrier Protein (ACP) is a protein that is important to the generation of lipids. Specifically, it aids in the production of fatty acids. Furthermore, ACP is just one component of the Fatty Acid Synthase enzyme, which is devoted to the synthesis of fatty acids.
To begin the process, ACP is first activated by having an acetyl-CoA molecule attached to it. Next, a compound called malonyl-CoA is attached to the bound acetyl-CoA. Malonyl-CoA is a three carbon compound, but upon being added to the acetyl-CoA, the malonyl-CoA becomes decarboxylated. The importance of this is that by producing carbon dioxide as a product, this helps to greatly drive the reaction forward.
Keep in mind that there are other chemical transformations happening when these malonyl-CoA molecules are being "stitched" together. Every time a malonyl-CoA is added, the carbon chain becomes increased by two more carbons. This keeps happening until, finally, a fatty acid is generated.
Acyl-Carrier Protein (ACP) is a protein that is important to the generation of lipids. Specifically, it aids in the production of fatty acids. Furthermore, ACP is just one component of the Fatty Acid Synthase enzyme, which is devoted to the synthesis of fatty acids.
To begin the process, ACP is first activated by having an acetyl-CoA molecule attached to it. Next, a compound called malonyl-CoA is attached to the bound acetyl-CoA. Malonyl-CoA is a three carbon compound, but upon being added to the acetyl-CoA, the malonyl-CoA becomes decarboxylated. The importance of this is that by producing carbon dioxide as a product, this helps to greatly drive the reaction forward.
Keep in mind that there are other chemical transformations happening when these malonyl-CoA molecules are being "stitched" together. Every time a malonyl-CoA is added, the carbon chain becomes increased by two more carbons. This keeps happening until, finally, a fatty acid is generated.
What is the role of lecithin-cholesterol acyltransferase (LCAT) in cholesterol metabolism and transport in the body?
What is the role of lecithin-cholesterol acyltransferase (LCAT) in cholesterol metabolism and transport in the body?
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Lecithin-cholesterol acyltransferase-LCAT adds a fatty acid to cholesterol, which can then be loaded onto high-density lipoproteins. Without the enzyme, cholesterol does not get to be transported by high density lipoproteins to the liver. Cholesterol then accumulates in tissue such as the eye and renal tissue. LCAT does impact cholesterol transport. Lipoprotein lipase is the enzyme that hydrolyzes fatty acids from triglycerides and cholesterol. Fatty acid synthase converts malonyl-CoA into palmitate. Acetyl-CoA carboxylase is the enzyme that incorporates acetyl-CoA into fatty acids.
Lecithin-cholesterol acyltransferase-LCAT adds a fatty acid to cholesterol, which can then be loaded onto high-density lipoproteins. Without the enzyme, cholesterol does not get to be transported by high density lipoproteins to the liver. Cholesterol then accumulates in tissue such as the eye and renal tissue. LCAT does impact cholesterol transport. Lipoprotein lipase is the enzyme that hydrolyzes fatty acids from triglycerides and cholesterol. Fatty acid synthase converts malonyl-CoA into palmitate. Acetyl-CoA carboxylase is the enzyme that incorporates acetyl-CoA into fatty acids.
Which of the following are true about fatty acid desaturase and lipid metabolism?
I. The enzyme is located in the endoplasmic reticulum.
II. The enzyme converts saturated fatty acids to unsaturated fatty acids.
III. The enzyme creates double bonds in fatty acid chains.
IV. The enzyme is important in production of arachidonic acid, an inflammatory pathway and cellular signal intermediate.
Which of the following are true about fatty acid desaturase and lipid metabolism?
I. The enzyme is located in the endoplasmic reticulum.
II. The enzyme converts saturated fatty acids to unsaturated fatty acids.
III. The enzyme creates double bonds in fatty acid chains.
IV. The enzyme is important in production of arachidonic acid, an inflammatory pathway and cellular signal intermediate.
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Fatty acid desaturases are located on the endoplasmic reticulum and convert saturated fatty acids to unsaturated fatty acids by producing double bonds. The enzymes have a N-terminal cytochrome b5-like domain. Arachidonic acid is a highly unsaturated fatty acid.
Fatty acid desaturases are located on the endoplasmic reticulum and convert saturated fatty acids to unsaturated fatty acids by producing double bonds. The enzymes have a N-terminal cytochrome b5-like domain. Arachidonic acid is a highly unsaturated fatty acid.
What is the role of citrate lyase in fatty acid synthesis?
I. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and coenzyme A.
II. It converts ATP to ADP and phosphate.
III. It converts ADP to ATP.
IV. It catalyzes the formation of citrate and coenzyme A from acetyl-CoA and oxaloacetate.
What is the role of citrate lyase in fatty acid synthesis?
I. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and coenzyme A.
II. It converts ATP to ADP and phosphate.
III. It converts ADP to ATP.
IV. It catalyzes the formation of citrate and coenzyme A from acetyl-CoA and oxaloacetate.
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Citrate crosses the mitochondrial matrix into the cytosol and is converted into acetyl-CoA and oxaloacetate by citrate lyase during fatty acid synthesis, as part of the citrate shuttle. The process requires hydrolysis of energy-rich ATP bonds.
Citrate crosses the mitochondrial matrix into the cytosol and is converted into acetyl-CoA and oxaloacetate by citrate lyase during fatty acid synthesis, as part of the citrate shuttle. The process requires hydrolysis of energy-rich ATP bonds.
Which of the following are fatty acid synthase components?
I. Malonyl CoA-ACP transacetylase.
II. Beta-ketoacyl synthase.
III. Beta-ketoacyl reductase.
IV. Acetyl CoA-ACP transacetylase.
Note: acyl carrier protein = ACP
Which of the following are fatty acid synthase components?
I. Malonyl CoA-ACP transacetylase.
II. Beta-ketoacyl synthase.
III. Beta-ketoacyl reductase.
IV. Acetyl CoA-ACP transacetylase.
Note: acyl carrier protein = ACP
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The role of fatty acid synthase is to synthesize fatty acids,more specifically to convert acetyl-CoA, malonyl-CoA, and NADPH to palmitate (a fatty acid) and NADP. It is a multienzyme complex consisting of 7 components: acetyl CoA-ACP transacetylase, malonyl-CoA-ACP transacetylase, Beta-ketoacyl synthase, Beta-ketoacyl reductase, Beta-hydroxyacyl dehydratase, enoyl reductase, thioesterase.
The role of fatty acid synthase is to synthesize fatty acids,more specifically to convert acetyl-CoA, malonyl-CoA, and NADPH to palmitate (a fatty acid) and NADP. It is a multienzyme complex consisting of 7 components: acetyl CoA-ACP transacetylase, malonyl-CoA-ACP transacetylase, Beta-ketoacyl synthase, Beta-ketoacyl reductase, Beta-hydroxyacyl dehydratase, enoyl reductase, thioesterase.
In mammals, the enzyme used to synthesize fatty acids is called mammalian fatty acid synthase. It has 7 components that all work together to synthesize a fatty acid chain.
If the DH subunit of the enzyme is mutated and cannot catalyze its proper reaction, which functional group would you expect to see on the resulting carbon chain?
In mammals, the enzyme used to synthesize fatty acids is called mammalian fatty acid synthase. It has 7 components that all work together to synthesize a fatty acid chain.
If the DH subunit of the enzyme is mutated and cannot catalyze its proper reaction, which functional group would you expect to see on the resulting carbon chain?
Tap to see back →
The DH subunit is a dehydratase, meaning it removes alcohol groups from carbon chains. If this subunit is mutated, the alcohol cannot be removed.
The DH subunit is a dehydratase, meaning it removes alcohol groups from carbon chains. If this subunit is mutated, the alcohol cannot be removed.
Malonyl-CoA is a potent inhibitor of carnitine palmitoyl transferase, which facilitates the movement of long-chain fatty acids into the mitochondria for beta-oxidation. This leads to decreased utilization of fatty acids for fuel.
If we wanted to eliminate this effect in a targeted manner, which enzyme would we seek to inhibit?
Malonyl-CoA is a potent inhibitor of carnitine palmitoyl transferase, which facilitates the movement of long-chain fatty acids into the mitochondria for beta-oxidation. This leads to decreased utilization of fatty acids for fuel.
If we wanted to eliminate this effect in a targeted manner, which enzyme would we seek to inhibit?
Tap to see back →
Because acetyl-CoA Carboxylase (ACC) is directly responsible for synthesis of malonyl-CoA, inhibiting it would be the most targeted approach. Inhibiting acyl-CoA dehydrogenase or pyruvate dehydrogenase would decrease available acetyl-CoA to ACC by inhibiting beta-oxidation and conversion of pyruvate to acetyl-CoA, but this would have a large impact on other biosynthetic pathways as well, due to the ubiquity of acetyl-CoA.
Because acetyl-CoA Carboxylase (ACC) is directly responsible for synthesis of malonyl-CoA, inhibiting it would be the most targeted approach. Inhibiting acyl-CoA dehydrogenase or pyruvate dehydrogenase would decrease available acetyl-CoA to ACC by inhibiting beta-oxidation and conversion of pyruvate to acetyl-CoA, but this would have a large impact on other biosynthetic pathways as well, due to the ubiquity of acetyl-CoA.
Which coenzyme is common to reactions catalyzed by pyruvate dehydrogenase and β-hydroxybutyrate dehydrogenase?
Which coenzyme is common to reactions catalyzed by pyruvate dehydrogenase and β-hydroxybutyrate dehydrogenase?
Tap to see back →
-hydroxybutyrate dehydrogenase catalyzes the interconversion of the ketone bodies acetoacetate and -hydroxybutyrate, which are transported out of liver cells into the blood to be used as fuel by the rest of the body, particularly during times of starvation. -hydroxybutyrate dehydrogenase’s only coenzyme is . As for the other answers: the pyruvate dehydrogenase complex converts pyruvate into acetyl-CoA, the key connection between glycolysis and the citric acid cycle, and this process uses a number of co-factors, including , thiamine pyrophosphate, lipoamide (the protein-bound form of lipoic acid), and, of course, coenzyme A (to make acetyl-CoA). Pyruvate dehydrogenase uses and depending on the cell type.
Which of the following is true about major lipoprotein metabolism pathways?
Which of the following is true about major lipoprotein metabolism pathways?
Tap to see back →
The endogenous, not the exogenous, pathway, involves the transformation of VDLDs into LDLs. Meanwhile, the exogenous, not the endogenous, pathway, involves transforming chylomicrons into remnants. The apolipoprotein in plasma (transporting cholesterol to the liver) which is the major component of HDL is A1, not B100. Macrophages do indeed oxidize LDLs and transform themselves into the foam cells which indicate atherosclerosis. This is one of the reasons that LDL cholesterol levels can indicate atherosclerosis (which is associated with increased risk of heart attack or stroke).
The endogenous, not the exogenous, pathway, involves the transformation of VDLDs into LDLs. Meanwhile, the exogenous, not the endogenous, pathway, involves transforming chylomicrons into remnants. The apolipoprotein in plasma (transporting cholesterol to the liver) which is the major component of HDL is A1, not B100. Macrophages do indeed oxidize LDLs and transform themselves into the foam cells which indicate atherosclerosis. This is one of the reasons that LDL cholesterol levels can indicate atherosclerosis (which is associated with increased risk of heart attack or stroke).
The enzyme Acyl-Carrier Protein (ACP) plays an important role in the biosynthesis of which of the following?
The enzyme Acyl-Carrier Protein (ACP) plays an important role in the biosynthesis of which of the following?
Tap to see back →
Acyl-Carrier Protein (ACP) is a protein that is important to the generation of lipids. Specifically, it aids in the production of fatty acids. Furthermore, ACP is just one component of the Fatty Acid Synthase enzyme, which is devoted to the synthesis of fatty acids.
To begin the process, ACP is first activated by having an acetyl-CoA molecule attached to it. Next, a compound called malonyl-CoA is attached to the bound acetyl-CoA. Malonyl-CoA is a three carbon compound, but upon being added to the acetyl-CoA, the malonyl-CoA becomes decarboxylated. The importance of this is that by producing carbon dioxide as a product, this helps to greatly drive the reaction forward.
Keep in mind that there are other chemical transformations happening when these malonyl-CoA molecules are being "stitched" together. Every time a malonyl-CoA is added, the carbon chain becomes increased by two more carbons. This keeps happening until, finally, a fatty acid is generated.
Acyl-Carrier Protein (ACP) is a protein that is important to the generation of lipids. Specifically, it aids in the production of fatty acids. Furthermore, ACP is just one component of the Fatty Acid Synthase enzyme, which is devoted to the synthesis of fatty acids.
To begin the process, ACP is first activated by having an acetyl-CoA molecule attached to it. Next, a compound called malonyl-CoA is attached to the bound acetyl-CoA. Malonyl-CoA is a three carbon compound, but upon being added to the acetyl-CoA, the malonyl-CoA becomes decarboxylated. The importance of this is that by producing carbon dioxide as a product, this helps to greatly drive the reaction forward.
Keep in mind that there are other chemical transformations happening when these malonyl-CoA molecules are being "stitched" together. Every time a malonyl-CoA is added, the carbon chain becomes increased by two more carbons. This keeps happening until, finally, a fatty acid is generated.
What is the role of lecithin-cholesterol acyltransferase (LCAT) in cholesterol metabolism and transport in the body?
What is the role of lecithin-cholesterol acyltransferase (LCAT) in cholesterol metabolism and transport in the body?
Tap to see back →
Lecithin-cholesterol acyltransferase-LCAT adds a fatty acid to cholesterol, which can then be loaded onto high-density lipoproteins. Without the enzyme, cholesterol does not get to be transported by high density lipoproteins to the liver. Cholesterol then accumulates in tissue such as the eye and renal tissue. LCAT does impact cholesterol transport. Lipoprotein lipase is the enzyme that hydrolyzes fatty acids from triglycerides and cholesterol. Fatty acid synthase converts malonyl-CoA into palmitate. Acetyl-CoA carboxylase is the enzyme that incorporates acetyl-CoA into fatty acids.
Lecithin-cholesterol acyltransferase-LCAT adds a fatty acid to cholesterol, which can then be loaded onto high-density lipoproteins. Without the enzyme, cholesterol does not get to be transported by high density lipoproteins to the liver. Cholesterol then accumulates in tissue such as the eye and renal tissue. LCAT does impact cholesterol transport. Lipoprotein lipase is the enzyme that hydrolyzes fatty acids from triglycerides and cholesterol. Fatty acid synthase converts malonyl-CoA into palmitate. Acetyl-CoA carboxylase is the enzyme that incorporates acetyl-CoA into fatty acids.
Which of the following are true about fatty acid desaturase and lipid metabolism?
I. The enzyme is located in the endoplasmic reticulum.
II. The enzyme converts saturated fatty acids to unsaturated fatty acids.
III. The enzyme creates double bonds in fatty acid chains.
IV. The enzyme is important in production of arachidonic acid, an inflammatory pathway and cellular signal intermediate.
Which of the following are true about fatty acid desaturase and lipid metabolism?
I. The enzyme is located in the endoplasmic reticulum.
II. The enzyme converts saturated fatty acids to unsaturated fatty acids.
III. The enzyme creates double bonds in fatty acid chains.
IV. The enzyme is important in production of arachidonic acid, an inflammatory pathway and cellular signal intermediate.
Tap to see back →
Fatty acid desaturases are located on the endoplasmic reticulum and convert saturated fatty acids to unsaturated fatty acids by producing double bonds. The enzymes have a N-terminal cytochrome b5-like domain. Arachidonic acid is a highly unsaturated fatty acid.
Fatty acid desaturases are located on the endoplasmic reticulum and convert saturated fatty acids to unsaturated fatty acids by producing double bonds. The enzymes have a N-terminal cytochrome b5-like domain. Arachidonic acid is a highly unsaturated fatty acid.
What is the role of citrate lyase in fatty acid synthesis?
I. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and coenzyme A.
II. It converts ATP to ADP and phosphate.
III. It converts ADP to ATP.
IV. It catalyzes the formation of citrate and coenzyme A from acetyl-CoA and oxaloacetate.
What is the role of citrate lyase in fatty acid synthesis?
I. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and coenzyme A.
II. It converts ATP to ADP and phosphate.
III. It converts ADP to ATP.
IV. It catalyzes the formation of citrate and coenzyme A from acetyl-CoA and oxaloacetate.
Tap to see back →
Citrate crosses the mitochondrial matrix into the cytosol and is converted into acetyl-CoA and oxaloacetate by citrate lyase during fatty acid synthesis, as part of the citrate shuttle. The process requires hydrolysis of energy-rich ATP bonds.
Citrate crosses the mitochondrial matrix into the cytosol and is converted into acetyl-CoA and oxaloacetate by citrate lyase during fatty acid synthesis, as part of the citrate shuttle. The process requires hydrolysis of energy-rich ATP bonds.
Which of the following are fatty acid synthase components?
I. Malonyl CoA-ACP transacetylase.
II. Beta-ketoacyl synthase.
III. Beta-ketoacyl reductase.
IV. Acetyl CoA-ACP transacetylase.
Note: acyl carrier protein = ACP
Which of the following are fatty acid synthase components?
I. Malonyl CoA-ACP transacetylase.
II. Beta-ketoacyl synthase.
III. Beta-ketoacyl reductase.
IV. Acetyl CoA-ACP transacetylase.
Note: acyl carrier protein = ACP
Tap to see back →
The role of fatty acid synthase is to synthesize fatty acids,more specifically to convert acetyl-CoA, malonyl-CoA, and NADPH to palmitate (a fatty acid) and NADP. It is a multienzyme complex consisting of 7 components: acetyl CoA-ACP transacetylase, malonyl-CoA-ACP transacetylase, Beta-ketoacyl synthase, Beta-ketoacyl reductase, Beta-hydroxyacyl dehydratase, enoyl reductase, thioesterase.
The role of fatty acid synthase is to synthesize fatty acids,more specifically to convert acetyl-CoA, malonyl-CoA, and NADPH to palmitate (a fatty acid) and NADP. It is a multienzyme complex consisting of 7 components: acetyl CoA-ACP transacetylase, malonyl-CoA-ACP transacetylase, Beta-ketoacyl synthase, Beta-ketoacyl reductase, Beta-hydroxyacyl dehydratase, enoyl reductase, thioesterase.
In mammals, the enzyme used to synthesize fatty acids is called mammalian fatty acid synthase. It has 7 components that all work together to synthesize a fatty acid chain.
If the DH subunit of the enzyme is mutated and cannot catalyze its proper reaction, which functional group would you expect to see on the resulting carbon chain?
In mammals, the enzyme used to synthesize fatty acids is called mammalian fatty acid synthase. It has 7 components that all work together to synthesize a fatty acid chain.
If the DH subunit of the enzyme is mutated and cannot catalyze its proper reaction, which functional group would you expect to see on the resulting carbon chain?
Tap to see back →
The DH subunit is a dehydratase, meaning it removes alcohol groups from carbon chains. If this subunit is mutated, the alcohol cannot be removed.
The DH subunit is a dehydratase, meaning it removes alcohol groups from carbon chains. If this subunit is mutated, the alcohol cannot be removed.
Malonyl-CoA is a potent inhibitor of carnitine palmitoyl transferase, which facilitates the movement of long-chain fatty acids into the mitochondria for beta-oxidation. This leads to decreased utilization of fatty acids for fuel.
If we wanted to eliminate this effect in a targeted manner, which enzyme would we seek to inhibit?
Malonyl-CoA is a potent inhibitor of carnitine palmitoyl transferase, which facilitates the movement of long-chain fatty acids into the mitochondria for beta-oxidation. This leads to decreased utilization of fatty acids for fuel.
If we wanted to eliminate this effect in a targeted manner, which enzyme would we seek to inhibit?
Tap to see back →
Because acetyl-CoA Carboxylase (ACC) is directly responsible for synthesis of malonyl-CoA, inhibiting it would be the most targeted approach. Inhibiting acyl-CoA dehydrogenase or pyruvate dehydrogenase would decrease available acetyl-CoA to ACC by inhibiting beta-oxidation and conversion of pyruvate to acetyl-CoA, but this would have a large impact on other biosynthetic pathways as well, due to the ubiquity of acetyl-CoA.
Because acetyl-CoA Carboxylase (ACC) is directly responsible for synthesis of malonyl-CoA, inhibiting it would be the most targeted approach. Inhibiting acyl-CoA dehydrogenase or pyruvate dehydrogenase would decrease available acetyl-CoA to ACC by inhibiting beta-oxidation and conversion of pyruvate to acetyl-CoA, but this would have a large impact on other biosynthetic pathways as well, due to the ubiquity of acetyl-CoA.