NAPLEX Question of the Day
Test your knowledge with a hand-picked multiple-choice question.
A 42-year-old man with newly diagnosed HIV-1 infection is being evaluated for antiretroviral therapy. His HLA-B*57:01 test returns positive. He has normal renal and hepatic function, no hepatitis B coinfection, and no prior antiretroviral exposure. The team initially plans to start a fixed-dose combination containing abacavir, dolutegravir, and lamivudine. Other medications include lisinopril and hydrochlorothiazide for hypertension. He denies drug allergies. Baseline CD4 count is 280 cells/mm3 and HIV RNA is 120,000 copies/mL. Blood pressure is controlled. He is motivated to start treatment promptly and asks whether any of his test results would change the medication selection. The pharmacist is consulted to recommend an appropriate regimen considering his pharmacogenetic profile.
Which of the following represents the most appropriate therapy adjustment for this patient?