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USMLE Step 1 · Lessons

USMLE Step 1 lessons

14 sections · 74 skills · work through the full outline skill by skill — read the long-form lesson or flip through the slide-style version.
Long-form lessonsSlide-style lessons

USMLE Step 1

Practice 74 skills across this outline.

Recommended next
Mitochondrial Disorders And Energy Failure
Biochemistry
Long-form lesson
Weighting distribution
14 categories
Biochemistry
7%
Biostatistics And Epidemiology
7%
Renal System
7%
Immunology
7%
Microbiology
7%
Pharmacology
7%

Skills

The comprehensive taxonomy of usmle step 1 — drill into a card to work its skills.

Biochemistry

12 core skills7% total weight
0/12 completed
12 skills to mastery
1
Mitochondrial Disorders And Energy FailureRecommended
Long-form
2
Amino Acid Metabolism And Urea CycleAvailable
Long-form
3
Biochemical Laboratory TechniquesAvailable
Long-form
4
Citric Acid Cycle And Oxidative PhosphorylationAvailable
Long-form
5
DNA Structure, Replication, And RepairAvailable
Long-form
6
Enzymes, Kinetics, And RegulationAvailable
Long-form
7
Glycolysis, Gluconeogenesis, And Glycogen MetabolismAvailable
Long-form
8
Inborn Errors Of MetabolismAvailable
Long-form
9
Lipid Metabolism And Ketone BodiesAvailable
Long-form
10
Pentose Phosphate Pathway And Redox BalanceAvailable
Long-form
11
Transcription, Translation, And RegulationAvailable
Long-form
12
Vitamins, Cofactors, And NutritionAvailable
Long-form

Biostatistics And Epidemiology

8 core skills7% total weight
0/8 completed
8 skills to mastery
1
Study Design And Evidence TypesAvailable
Long-form
2
Bias And ConfoundingAvailable
Long-form
3
Data InterpretationAvailable
Long-form
4
Diagnostic Test PerformanceAvailable
Long-form
5
Ethics And Research PrinciplesAvailable
Long-form
6
Risk Measures And ScreeningAvailable
Long-form
7
Statistical TestsAvailable
Long-form
8
Statistical InferenceAvailable
Long-form

Renal System

3 core skills7% total weight
0/3 completed
3 skills to mastery
1
Acid–Base And Electrolyte RegulationAvailable
Long-form
2
Renal PathophysiologyAvailable
Long-form
3
Renal Physiology And FiltrationAvailable
Long-form

Immunology

8 core skills7% total weight
0/8 completed
8 skills to mastery
1
Antigen Presentation And CytokinesAvailable
Long-form
2
Autoimmunity And Self-ToleranceAvailable
Long-form
3
HIV And RetrovirusesAvailable
Long-form
4
Hypersensitivity ReactionsAvailable
Long-form
5
Immunodeficiency DisordersAvailable
Long-form
6
Innate And Adaptive ImmunityAvailable
Long-form
7
Transplantation ImmunologyAvailable
Long-form
8
Vaccines And Immune MemoryAvailable
Long-form

Microbiology

8 core skills7% total weight
0/8 completed
8 skills to mastery
1
Antimicrobial ResistanceAvailable
Long-form
2
Antimicrobial MechanismsAvailable
Long-form
3
Bacterial Toxins And Immune EvasionAvailable
Long-form
4
Bacterial Structure, Classification, And VirulenceAvailable
Long-form
5
Fungi And ParasitesAvailable
Long-form
6
Host–Pathogen InteractionsAvailable
Long-form
7
Microbial Laboratory IdentificationAvailable
Long-form
8
Viral Structure And ReplicationAvailable
Long-form

Pharmacology

9 core skills7% total weight
0/9 completed
9 skills to mastery
1
Antimicrobial PharmacologyAvailable
Long-form
2
Autonomic PharmacologyAvailable
Long-form
3
Cardiovascular PharmacologyAvailable
Long-form
4
Central Nervous System PharmacologyAvailable
Long-form
5
Drug Toxicity And Adverse EffectsAvailable
Long-form
6
Endocrine PharmacologyAvailable
Long-form
7
PharmacokineticsAvailable
Long-form
8
Pharmacodynamics And Receptor TheoryAvailable
Long-form
9
Toxicology And AntidotesAvailable
Long-form

Hematology And Oncology

2 core skills7% total weight
0/2 completed
2 skills to mastery
1
Cancer Biology And NeoplasiaAvailable
Long-form
2
Hematologic Physiology And DisordersAvailable
Long-form

Genetics

7 core skills7% total weight
0/7 completed
7 skills to mastery
1
Cancer GeneticsAvailable
Long-form
2
Chromosomal DisordersAvailable
Long-form
3
Genetic Testing And DiagnosticsAvailable
Long-form
4
Inherited Metabolic And Single-Gene DisordersAvailable
Long-form
5
Mendelian Inheritance And PedigreesAvailable
Long-form
6
Mitochondrial And Non-Mendelian InheritanceAvailable
Long-form
7
Molecular Genetics And Gene ExpressionAvailable
Long-form

Cardiovascular System

3 core skills7% total weight
0/3 completed
3 skills to mastery
1
Cardiac PathophysiologyAvailable
Long-form
2
Cardiac Physiology And HemodynamicsAvailable
Long-form
3
Vascular And Blood Pressure DisordersAvailable
Long-form

Respiratory System

3 core skills7% total weight
0/3 completed
3 skills to mastery
1
Control Of Breathing And RegulationAvailable
Long-form
2
Pulmonary PathophysiologyAvailable
Long-form
3
Respiratory Physiology And Gas ExchangeAvailable
Long-form

Endocrine System

3 core skills7% total weight
0/3 completed
3 skills to mastery
1
Endocrine PathophysiologyAvailable
Long-form
2
Hormone Physiology And RegulationAvailable
Long-form
3
Metabolic And Growth DisordersAvailable
Long-form

Gastrointestinal System

3 core skills7% total weight
0/3 completed
3 skills to mastery
1
Gastrointestinal Physiology And MotilityAvailable
Long-form
2
Gastrointestinal PathophysiologyAvailable
Long-form
3
Hepatobiliary And Pancreatic PathophysiologyAvailable
Long-form

Nervous System

3 core skills7% total weight
0/3 completed
3 skills to mastery
1
Neuroanatomy And LocalizationAvailable
Long-form
2
NeuropathologyAvailable
Long-form
3
NeurophysiologyAvailable
Long-form

Reproductive System

2 core skills7% total weight
0/2 completed
2 skills to mastery
1
Reproductive Physiology And DevelopmentAvailable
Long-form
2
Reproductive PathophysiologyAvailable
Long-form