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Example Questions
Example Question #21 : Second Messengers
In a G protein-coupled receptor, the activation of an inhibitory G protein will lead to which of the following?
Possible Answers:
An inactivated alpha subunit of the G protein
Downstream activation of PKA
Adenyl cyclase hydrolysis of ATP
The activation of adenylyl cyclase
The decrease in cAMP
Correct answer:
The decrease in cAMP
Explanation:
With an inhibitory G protein, the binding of a ligand and stimulation of the receptor will activate the alpha subunit of the G protein, however since it is an inhibitory G protein, it will not go on to activate adenyl cyclase. With no activation of Adenyl cyclase it will lead to decrease cAMP and other secondary messengers.
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