The word "fatal" is related to the word "fate," which indicates the idea that something is meant to happen. However, "fatal" indicates a particular kind of "fated" occurrence, namely death. Things that happen by "fate" often are ominous or threatening. A "fatal" wound is one that is likely to kill. Therefore, the best synonyms will reflect either complete destruction or the causing of death. While something that is fatal might be depressing, something that is depressing really is not deadly (at least, not necessarily). The two words describe two different things. The best option is "deadly," meaning likely to kill.

When we "prohibit" something, we ban it or forbid it from being done. "Prohibited substances" are things that cannot be taken into a given area. For example, beer is often a prohibited substance in gaming arenas, meaning that you are not permitted to take it into such areas. The best option among those given is "forbidden," which indicates such banning. Although someone can be condemned for having such a prohibited thing, that is not what is indicated by the word "prohibition" itself. Likewise, a prohibited substance might be "dangerous." This does not mean the same thing as "prohibited" itself.

Bungled means failed or messed-up. To further help you, appropriate means right for the moment, good; inappropriate means not proper, bad.

"Painstaking" means accomplished with care and attention to detail. "Careful" is therefore the word that most closely matches the definition. "Painful" is a tempting choice, but the word "painstaking" actually has little to do with physical pain. "Reckless" is the opposite of "painstaking," and "malicious," which means intentionally causing harm, is unrelated to the definition.  

Estranged refers to a person, often a family member, who is no longer close with another person, or alienated from him/her; therefore, "distant" is the best answer.

Diligent, which is often used to describe someone as hardworking, also means displaying care or being dutiful in one's work. "Conscientious" means the same thing, someone who works well and thoroughly. 

The word “vacant” means empty or, when referring to buildingsor rooms, not occupied. The word “ashamed” describes a feeling where you feel bad or guilty about something bad you have done.

"Disoriented" means to be in a state in which one has lost one's bearings and is confused as to where things are located. It most closely means the word "confused." The other answer choices are not related in meaning to the word "disoriented."

"Affiliated" means connected to an organization, individual, or cause. Likewise, "associated" means related to something. Given how similar these meanings are to one another, "affiliated" and "associated" are synonyms.

Something that is "strenuous" is very challenging, whether it be physically or mentally challenging. Thus, "difficult" is the best synonym because something that is "difficult" is not easy to complete. Thus, "strenuous" and "difficult" are synonyms.