MCAT Biology : Biology

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #13 : Hemoglobin, Blood Cells, And Blood Proteins

Hemoglobin is the principal oxygen-carrying protein in humans. It exists within erythrocytes, and binds up to four diatomic oxygen molecules simultaneously. Hemoglobin functions to maximize oxygen delivery to tissues, while simultaneously maximizing oxygen absorption in the lungs. Hemoglobin thus has a fundamentally contradictory set of goals. It must at once be optimized to absorb oxygen, and to offload oxygen. Natural selection has overcome this apparent contradiction by making hemoglobin exquisitely sensitive to conditions in its microenvironment.

One way in which hemoglobin accomplishes its goals is through the phenomenon of cooperativity. Cooperativity refers to the ability of hemoglobin to change its oxygen binding behavior as a function of how many other oxygen atoms are bound to the molecule. 

Fetal hemoglobin shows a similar pattern of cooperativity, but has unique binding characteristics relative to adult hemoglobin. Fetal hemoglobin reaches higher saturation at lower oxygen partial pressure.

Because of cooperativity, adult and fetal oxygen-hemoglobin dissociation curves appear as follows.

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Beyond its ability to carry oxygen, hemoglobin is also effective as a blood buffer. The general reaction for the blood buffer system of hemoglobin given below.

H+ + HbO2 ←→ H+Hb + O2

 

Hemoglobin is the most important component of red blood cells. How are red blood cells different from other cells of the body?

Possible Answers:

They lack a nucleus

They lack a cell membrane

They contain protein support for their membranes

They are larger than all other cells

They are produced in the thymus

Correct answer:

They lack a nucleus

Explanation:

Red blood cells are unique in that they lack a nucleus and are functionally just "bags of hemoglobin." They are among the most specialized cells, doing little else but transporting oxygen in the blood.

The choice indicating protein support for the membrane may have also been tempting, and is true. This characteristic, however, is shared by other cells of the body. Also remember that red blood cells are produced by red bone marrow (and sometimes the liver), while certain white blood cells mature in the thymus.

Example Question #911 : Biology

Which of the following is a cause of alkalosis?

Possible Answers:

Hyperventilation

Strenuous exercise leading to a buildup of lactate

Increased parietal cell activity

High levels of  in the blood

Renal dysfunction leading to a buildup of urea and creatinine

Correct answer:

Hyperventilation

Explanation:

Hyperventilation is a classic example of a process that can cause alkalosis, or basicity of the bloodstream. Hyperventilation can cause a net loss of CO2. Low levels of CO2 can cause respiratory alkalosis via reduction of carbonate in the blood. Lactate—also known as lactic acid—is a product of anaerobic respiration, and decreases blood pH. Increased levels of urea and creatinine indicate renal acidosis, a form of metabolic acidosis, which occurs when the kidney does not remove enough acid from the body. 

Example Question #912 : Biology

A scientist takes a group of erythrocytes (red blood cells) and places them in a beaker containing a solution. The cells begin to shrink and eventually lyse. What can be concluded about the solution?

Possible Answers:

The solution was hypertonic to the erythrocytes

The solution was isotonic to the erythrocytes

The solution contained albumin

The solution contained bicarbonate

The solution was hypotonic to the erythrocytes

Correct answer:

The solution was hypertonic to the erythrocytes

Explanation:

Placing erythrocytes in a hypertonic solution would cause them to shrink and burst, becuase water from the erythrocytes would move from high to low concenration (inside the cells to the outside hypertonic environment). Albumin and bicarbonate would have no effect, because they are normal components of blood. Placing them in a hypotonic solution would cause them to swell up.

Example Question #913 : Biology

What could the blood pH of a person who has blood acidosis (more acidic blood than normal) possibly be?

Possible Answers:

7.5

Either 7.5 or 7.2

6.8

Either 7.2 or 6.8

7.2

Correct answer:

Either 7.2 or 6.8

Explanation:

The normal pH of blood is around 7.3, which means blood is normally slightly basic. A truly neutral pH is 7.0. Whenever the pH of blood is under 7.3 (not 7.0) it is considered acidosis, and so our answer is either 7.2 or 6.8.

Example Question #914 : Biology

Which statement regarding blood typing is correct?

Possible Answers:

A person with B- blood can donate to a person whose blood type is AB+.

A woman with Rh- blood is at risk for developing erythroblastosis fetalis during her first pregnancy if the fetus is Rh+.

The presence of the Rh factor is coded for by a recessive allele.

A person with O- blood can receive a blood donation from someone with O+ blood.

A person with AB- blood can donate to a person whose blood type is O-.

Correct answer:

A person with B- blood can donate to a person whose blood type is AB+.

Explanation:

The AB+ blood type is known as the "universal recipient" type, therefore, people with any blood type can donate to an AB+ individual.

As for the incorrect answers, a person with O- blood has the "universal donor" type, and can only receive blood from other O- individuals. Erythroblastosis fetalis, also known as hemolytic disease of the newborn, cannot occur during a woman's first pregnancy because her body has not yet produced anti-Rh antibodies. Finally, Rh factor presence is a genetically dominant condition.

Example Question #23 : Hemoglobin, Blood Cells, And Blood Proteins

Which of the following accurately represents the entire composition of blood?

Possible Answers:

Serum, erythrocytes, leukocytes, platelets

Erythrocytes, leukocytes, platelets

Plasma, erythrocytes, leukocytes, platelets

Serum, plasma, erythrocytes, leukocytes, platelets

Correct answer:

Plasma, erythrocytes, leukocytes, platelets

Explanation:

Human blood contains 55% plasma and 45% cells. The cells include erythrocytes (red blood cells), leukocytes (white blood cells), and thrombocytes (platelets). Plasma is largely composed of water, protein (albumin), and clotting factors.

Note that blood serum is simply blood plasma with the clotting factor elements (fibrinogen) removed.

Example Question #901 : Systems Biology And Tissue Types

Which of the following most accurately depicts the process of clotting?

Possible Answers:

Prothrombin is released and activates thrombin. Thrombin converts fibrinogen to fibrin, which stimulates the secretion of thromboplastin. Thromboplastin recruits elements of the blood to form a clot.

Thromboplastin is released and converts fibrinogen to fibrin, which recruits elements of the blood to form a clot.

Thromboplastin aggregates platelets to form a clot; fibrin and fibrinogen are structural elements of cells that are not related to clotting

Thromboplastin is released and converts prothrombin to thrombin. Thrombin converts fibrinogen to fibrin, which recruits elements of the blood to form a clot.

Correct answer:

Thromboplastin is released and converts prothrombin to thrombin. Thrombin converts fibrinogen to fibrin, which recruits elements of the blood to form a clot.

Explanation:

Thromboplastin is released when damage occurs to a tissue. Prothrombin and fibrinogen are both present in the blood. When thromboplastin interacts with the blood, it converts prothrombin to its active state, thrombin. Thrombin then cleaves fibrinogen, converting it to its active state, fibrin. Fibrin is exceptional at forming cross-linked mesh-like interactions, and in doing so traps passing blood cells and plasma proteins. This blockage and accumulation of blood elements becomes the clot.

Example Question #92 : Circulatory System

Albumin is created in the liver and is an important protein found in the blood. If a vial of blood is centrifuged, in which of the following layers would albumin be found?

Possible Answers:

The plasma layer

The leukocyte layer

The buffy coat layer

The red blood cell layer

Correct answer:

The plasma layer

Explanation:

When centrifuged, blood will divide into three parts: the plasma layer, the buffy coat layer, and the red blood cell layer. The plasma layer contains albumin, immunoglobulins, and blood clotting factors. The buffy coat is composed of leukocytes, and the red blood cell layer is composed of erythrocytes.

Example Question #915 : Biology

Which of the following is known as "bad cholesterol"?

Possible Answers:

Low-density lipoprotein cholesterol

Total cholesterol

High-density lipoprotein cholesterol

High-density lipoprotein and Low-density lipoprotein cholesterol

Correct answer:

Low-density lipoprotein cholesterol

Explanation:

Low-density lipoprotein (LDL) cholesterol are considered to be "bad cholesterol" because it transports fat molecules to arteries and attracts macrophages, leading to atherosclerosis. Alternatively, high-density lipoprotein (HDL) cholesterol is considered to be "good cholesterol" because it removes fat molecules from macrophages, decreasing the risk of atherosclerosis.

Example Question #916 : Biology

Coagulation factor II, also called prothrombin, plays an important role in the clotting process. A very rare genetic mutation causes a deficiency of coagulation factor II, resulting in a form of hemophilia due to a mutation affecting a protein produced by which organ?

Possible Answers:

Lungs

Spleen

Liver

Heart

Correct answer:

Liver

Explanation:

Coagulation Factor II (prothrombin) is a protein produced in the liver. Prothrombin is modified after translation to produce thrombin. Thrombin is an enzyme that catalyzes coagulation reactions and results in reduced blood loss. Factor II deficiency is an autosomal recessive mutation that can result in defects in blood clotting.

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