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Example Questions
Example Question #5 : Cell Biology, Molecular Biology, And Genetics
Human chromosomes are divided into two arms, a long q arm and a short p arm. A karyotype is the organization of a human cell’s total genetic complement. A typical karyotype is generated by ordering chromosome 1 to chromosome 23 in order of decreasing size.
When viewing a karyotype, it can often become apparent that changes in chromosome number, arrangement, or structure are present. Among the most common genetic changes are Robertsonian translocations, involving transposition of chromosomal material between long arms of certain chromosomes to form one derivative chromosome. Chromosomes 14 and 21, for example, often undergo a Robertsonian translocation, as below.
A karyotype of this individual for chromosomes 14 and 21 would thus appear as follows:
Though an individual with aberrations such as a Robertsonian translocation may be phenotypically normal, they can generate gametes through meiosis that have atypical organizations of chromosomes, resulting in recurrent fetal abnormalities or miscarriages.
In der(14,21), which region of a chromosome might you expect to find in the center of its structure?
Heavily methylated region
Centromere
Telomere
Guanine-cytosine rich region
Histone-rich region
Telomere
Telomeres are present at the ends of chromosomes. If one really understands the passage, one can see that Robertsonian translocation places the ends of chromosomes together to form the middle of the derivative chromosome. We would expect to find telomeres in this region.
Example Question #3 : Cell Biology, Molecular Biology, And Genetics
A man with type AB blood marries a woman with type A blood. Which of the following blood types might their sons inherit?
Type A or type O
Type AB only
Type B or type O
Type A or type AB
Type A, type B, or type AB
Type A, type B, or type AB
The genotype of the father is definitely AB. The genotype of the mother is either AA or AO.
Below are the Punnett squares that show that types A, B, and AB are possible. Note that the genotype AO will result in a type A phenotype, while the genotype BO will result in a type B phenotype.
Example Question #1 : Genetics
Which of the following refers to the region of RNA responsible for binding ribosomes during prokaryotic translation?
Shine-Dalgarno sequence
TATA box
Terminator
Promoter
Shine-Dalgarno sequence
The Shine-Dalgarno sequence is located just upstream of the start codon on a strand of prokaryotic RNA. The sequence functions to bind the rRNA of the ribosome, recruiting it to the proper location to initial translation.
Example Question #1 : Cell Biology, Molecular Biology, And Genetics
Which type of RNA is responsible for transporting amino acids during translation?
rRNA
mRNA
htRNA
tRNA
tRNA
tRNA, or transfer RNA, contains two functional regions. One region is the anticodon—a sequence of three nucleotides that corresponds to the coding region of an mRNA molecule. The anticodon-codon sequences define the identity of the amino acid coded for by that particular region of the gene. The second functional region of tRNA is bound to the amino acid that corresponds to the particular anticodon-codon sequence. tRNA will transport this amino acid to a ribosome, bind to the codon on the mRNA, and release the amino acid for incorporation into the growing polypeptide.
Example Question #9 : Genetics
A researcher is studying a population of insects and notices that 60% have red eyes, 30% have apricot eyes, 5% have white eyes, and 5% have pink eyes. Which of these eye colors would be designated the wild type?
Apricot
Pink
White
Red
Red
Wild type is a term that refers to the most prevalent phenotype for a certain trait. Because red eye color seems to be the majority, it would be considered the wild type. The other colors (white, pink, and apricot) are likely due to slight genetic variations of the gene that codes for eye color.
Example Question #1 : Mendel And Inheritance Patterns
Pea plants have two independently assorted genes that code for seed shape (round or wrinkled) and seed color (yellow or green), respectively. A researcher crosses two pea plants and observes that all F1 offspring have the same phenotype: round shape and yellow seeds. He then performs a test cross with an F1 offspring and observes four different phenotypes in a 1:1:1:1 ratio. Based on this information the researcher concludes the genotypes of the parents.
The researcher notices that round seeds occur naturally in the environment. Based solely on this information, what can the researcher conclude about the round phenotype?
I. It is dominant
II. It is recessive
III. It is wild type
I and III
I and II
III only
I only
III only
The question states "based SOLELY on this information." The only information you have is that the round phenotype occurs naturally in the environment.
By definition, a wild type phenotype is something that occurs naturally in the environment (naturally in the "wild"). This observation makes statement III true.
By examining the given passage, we can also conclude that the yellow phenotype is dominant; however, this conclusion cannot be reached solely from the information provided in the question. The only conclusion you can make from this information is that the round phenotype is wild type. Also, remember that a wild type allele isn’t always dominant; there are recessive wild type alleles. For example, the wild type allele for Drosophila wings is recessive, whereas the mutant wrinkled wings are dominant.
Example Question #11 : Genetics
If two parents do not have cystic fibrosis but are carriers for the disease, what are their odds of having a child with cystic fibrosis?
100%
75%
50%
25%
0%
25%
Carriers are heterozygotes. In the case of recessive inheritance, a carrier will not know that they are carrying a single allele for the disease. In the Punnett Square, crossing two heterozygotes will result in 25% homozygous dominant and 50% heterozygous carriers, with 25% homozygous recessive who will have cystic fibrosis
Example Question #11 : Cell Biology, Molecular Biology, And Genetics
Sickle cell anemia is an autosomal recessive trait. If a mother, who is a carrier of the trait, mates with a man who is also a carrier of the trait, what is the possibility that a boy born to the couple will have the disease?
75%
12.5%
50%
25%
0%
25%
There is a 25% chance that a child, regardless of sex, will have the disease. Sickle cell anemia is an autosomal recessive trait, so female and male offsprings are affected equally. Two carriers that mate will have a 25% chance of having a child with the disease, 50% chance of having a child who is also a carrier, and 25% chance of having a child who is normal, meaning he/she has two normal alleles. This can be seen by drawing a Punnett square for two heterozygous parents.
Example Question #12 : Genetics
The gene for muscular dystrophy is X-linked. A female carrier and an unaffected male have one daughter together. The daughter has a son with an unaffected male. What is the probability that the son will not be affected?
0%
75%
50%
25%
75%
First, we know that muscular dystrophy must be recessive, as the grandmother in the question is a carrier.
Below is the Punnett Square for the grandparents, where the mother is a carrier and father is unaffected. X represents an unaffected allele, while X' represents the allele for dystrophy. The probability their daughter is a carrier is 50%, and the probability she is unaffected is 50%.
If the daughter is a carrier, the Punnett square between her and an unaffected male (the father) would be identical to that of the grandparents. In this case, the chance of the son being affected is 50%.
If the daughter is not a carrier, then her son cannot be affected.
In order for the son to be affected, two events must take place: the daughter must be a carrier (50% chance), and the son must inherit the affected allele (50% chance).
There is a 25% chance that the son will be affected; thus, there is a 75% chance that he will be unaffected.
|
X’ |
X |
X |
X’X |
XX |
Y |
X’Y |
XY |
Example Question #13 : Genetics
A species of flower can have only two colors: purple or white. Purple is dominant to white. The color trait is determined by complete dominance, and each flower receives two copies of the gene.
A test cross confirms that a random purple flower is homozygous dominant for the color trait. What flower type was crossed with the wild purple flower to determine this result?
Heterozygous flower
Purple flower
White flower
Homozygous purple flower
White flower
A test cross takes place when an unknown flower is crossed with a flower that is homozygous recessive for the trait. This is used to determine if the unknown flower is heterozygous or homozygous dominant. In this case, a flower recessive for the color trait will be white.
Crossing with a known homozygous recessive flower allows us to determine if the purple flower is homozygous dominant or heterozygous. If all offspring are purple, then the purple parent is homozygous dominant. If any white offspring are produced, then the purple parent must carry the white allele and be heterozygous.
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